|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We digitised tissue sections of both diagnostic and surgical samples of breast tumours from 768 patients enrolled in the Neo-tAnGo randomized controlled trial.
|
26882907 |
2016 |
|
Coronary Artery Disease
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations.
|
24125424 |
2013 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Thus, functional relevant loss of TANGO expression may contribute to general tumor development and progression, and may provide a new target for therapeutic strategies.
|
17786351 |
2007 |
|
Down Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The proposal relies on stimulating the cognitive visual-motor skills of individuals with Down Syndrome (DS) using exercises with a gestural interaction platform based on the KINECT sensor named TANGO:H, the goal being to improve them.
|
31540138 |
2019 |
|
Complete Trisomy 21 Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The proposal relies on stimulating the cognitive visual-motor skills of individuals with Down Syndrome (DS) using exercises with a gestural interaction platform based on the KINECT sensor named TANGO:H, the goal being to improve them.
|
31540138 |
2019 |
|
Coronary heart disease
|
0.150 |
GeneticVariation
|
disease |
BEFREE |
The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured.
|
21804106 |
2012 |
|
Nocturia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The acronym TANGO stands for Targeting the individual's Aetiology of Nocturia to Guide Outcomes.
|
28075514 |
2017 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The MIA3 mutant allele showed predominant mRNA expression in normal, cancer and precancerous tissues.
|
28742792 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The MIA3 mutant allele showed predominant mRNA expression in normal, cancer and precancerous tissues.
|
28742792 |
2017 |
|
melanoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Recently, we identified TANGO as a tumor suppressor in malignant melanoma.
|
17786351 |
2007 |
|
Tumor Progression
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Our studies, therefore, indicate that reduction of TANGO expression contributes to tumor progression.
|
17044017 |
2006 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Our studies present for the first time the down-regulation of TANGO in colon and hepatocellular carcinoma and provide the first indications for a tumor suppressor role of the TANGO gene in human colon and hepatocellular carcinoma.
|
17786351 |
2007 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our studies present for the first time the down-regulation of TANGO in colon and hepatocellular carcinoma and provide the first indications for a tumor suppressor role of the TANGO gene in human colon and hepatocellular carcinoma.
|
17786351 |
2007 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Our results suggest that MIA, MIA2, and TANGO may be useful diagnostic and therapeutic molecular targets in human malignancies.
|
27145272 |
2016 |
|
Myocardial Infarction
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
Our results establish two SNPs, rs17465637 in MIA3 and rs599839 near SORT1 as significant risk factors for MI in the American Genebank Caucasian population.
|
21463265 |
2011 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MicroRNA-222 influences migration and invasion through MIA3 in colorectal cancer.
|
28855850 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
MicroRNA-222 influences migration and invasion through MIA3 in colorectal cancer.
|
28855850 |
2017 |
|
melanoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
MIA has a pivotal role in the progression and metastasis of melanoma; MIA2 and TANGO have been suggested to possess tumor-suppressive functions; and OTOR is uniquely expressed in cochlea of the inner ear.
|
29655307 |
2018 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MIA has a pivotal role in the progression and metastasis of melanoma; MIA2 and TANGO have been suggested to possess tumor-suppressive functions; and OTOR is uniquely expressed in cochlea of the inner ear.
|
29655307 |
2018 |
|
Coronary Arteriosclerosis
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease.
|
24125424 |
2013 |
|
Coronary heart disease
|
0.150 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease.
|
24125424 |
2013 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Melanoma inhibitor protein 3 (MIA3) is required for the export of collagen VlI (COL7A1) from the endoplasmic reticulum and it appears to be a tumor suppressor of malignant melanoma.
|
22577832 |
2012 |
|
Coronary heart disease
|
0.150 |
GeneticVariation
|
disease |
GWASDB |
Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
|
21966275 |
2011 |
|
Coronary Artery Disease
|
0.440 |
Biomarker
|
disease |
CTD_human |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Coronary Arteriosclerosis
|
0.330 |
Biomarker
|
disease |
CTD_human |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |